Changes in kinetic properties of tyrosine hydroxylase due to dopamine effect on the external synaptosomal membrane.
نویسندگان
چکیده
منابع مشابه
اثر دویدن روی نوارگردان بر سطح IGF-1 در جسم مخطط موش‌های پارکینسونی شده با القای 6-هیدروکسی دوپامین
Background & Aims: There is no agreement on the protective effect of exercise on neurodegeneration processes, and the mechanisms responsible for exercise benefits in Parkinson disease (PD) yet. In this study we investigated the protective effect of 4 weeks of treadmill running with low intensity on the IGF-1, dopamine and tyrosine hydroxylase levels in the striatum of parkinsonian rats ind...
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Introduction: Astrocyte dysfunction is the common pathology resulting in failure of astrocyte-neuron interaction in neurological diseases, including Parkinson’s Disease (PD). To date, only few experimental models of selective ablation of astrocytes are known. The aim of present study was to evaluate the effect of striatal injections of selective glial toxin L-aminoadipic acid (L-AA) on the loco...
متن کاملActivation by cyclic 3':5'-adenosine monophosphate of tyrosine hydroxylase in the rat brain.
Membrane-permeable derivatives of cyclic AMP (cAMP) produced concentration-dependent increases in activity of tyrosine hydroxylase (L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2) in membrane-limited nerve endings (synaptosomes) prepared from three regions of rat brain. Increased hydroxylation occurred even after preincubation and removal of dibutyryl cycl...
متن کاملEFFECTS OF CATECHOLAMINES ON DOPAMINE AND SEROTONIN SYNTHESIS IN RAT BRAIN STRIATAL SYNAPTOSOMES: THE ROLE OF PRESYNAPTIC RECEPTORS AND THE SYNAPTOSOMAL REUPTAKE MECHANISM.
The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...
متن کاملDopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane.
Recent work has shown substantial alterations in NMDA receptor subunit expression, assembly, and phosphorylation in the dopamine-depleted striatum of a rodent 6-hydroxydopamine model of Parkinson's disease. These modifications are hypothesized to result from the trafficking of NMDA receptors between subcellular compartments. Here we show that in rat striatal tissues the NR2A and NR2B subunits i...
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ورودعنوان ژورنال:
- Annali dell'Istituto superiore di sanita
دوره 18 1 شماره
صفحات -
تاریخ انتشار 1982